Angela Catherine Borgia was born in Velletri on 14 June 1694 in a large family that had vast properties in that territory. The father was an important collector of works of art and ancient objects.

Every day in the family the Liturgy of the Virgin was recited and in the evening the Rosary, Angela Catherine loved to prepare in the house of the altars around which, at times, the family gathered in prayer. Their parish was the Cathedral of St. Clement.

Her elder brother Camillo continued to live in the palace of Velletri, while the other brothers and sisters of hers dedicated their lives to the Lord.

Among them we can find Alessandro, who a man of vast culture and became an important prelate. In 1716 he was appointed bishop of Nocera Umbra and in 1724 archbishop of Fermo.

 In 1729 her brother Fabrizio was appointed bishop of Ferentino.

Another brother of hers was abbot, another Knight of Malta, one did his religious profession in the Order of the Discalced Carmelites.

A sister of hers was a companion of Angela Catherine among the Augustinians of Saint Lucy "in Selci".

The illustrious cardinal Stefano Borgia (1731-1804) was a nephew of theirs.

Angeluccia, as they called her in the family, was concerned about the needs of the service personnel. The study and the housework were alternated with prayers and spiritual songs, at times it was absent and aroused a certain curiosity. Once, a servant saw her while she was praying in an isolated corner of the house.

Despite her young age, her thoughts were taken into consideration in her family.

Her desire to consecrate herself to the Lord matured soon in her soul. One day she spoke about it in her family where, however, there was no shortage of vocations, but she did not find the consent of the mother immediately. The providence sent there a the blessed Antonio Baldinucci to help her. He had already been in Velletri for some popular missions.

The Jesuit priest convinced "Donna Cecilia", her mother, and then they chose to direct her towards the ancient Roman monastery of "S. Lucia in Selci", which was already known in her family.

The Servant of God was about twenty years old. As she arrived in Rome, she expressed only her desire to go and pray the Virgin Mary, named "Salus Populi Romani" (Salvation of the Roman People), in the church of "Santa Maria Maggiore". She made her vestition ceremony on February 24, 1718.